![]() We noted the angle of the sides and the handle and weighed each skillet. We considered the shape and weight of each pan.(See our tips for cleaning cookware in our care and maintenance section below.) Although discoloration doesn’t affect a pan’s performance, it’s an aesthetic issue to consider before purchasing your skillet. Easy to clean: Many of the skillets we tested discolored over medium-high heat, with some acquiring a dark gray hue that we couldn’t scrub off.Unfortunately, any warping that occurs to your pan is permanent. It should also be durable enough so it doesn’t warp over high heat on the stovetop. Resistant to high heat: A pan needs to be able to withstand high temperatures of at least 500 ☏, which rules out most cheap pans.We recommend going to a kitchen store to hold a few pans to see what you like before you invest. Some of our testers with larger hands preferred wide, rounded handles those with smaller hands often preferred narrower handles. The handle angle is also important-if it’s too high, tossing food while sautéing can be awkward. A comfortable, oven-safe handle: Oven-safe riveted handles are also a must so that the pan can go directly from the stovetop to the oven or broiler.We’ve found skillets weighing between 2 and 3.5 pounds are lightweight enough to comfortably toss ingredients. ![]() Heavy pans are also more difficult to pick up or maneuver with one hand. If a skillet is too heavy, it will retain too much heat and respond slowly when you adjust the temperature.
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The best example of a successful application of the model is the regulation of hemoglobin function. The MWC model proved very popular in enzymology, and pharmacology, although it has been shown inappropriate in a certain number of cases. It cannot explain negative cooperativity. positive cooperativity) as change in concentration of ligand over a small range will lead to a large increase in the proportion of molecules in the R state, and thus will lead to a high association of the ligand to the protein. This model explains sigmoidal binding properties (i.e. R ¯ = ( 1 + α ) n ( 1 + α ) n + L ⋅ ( 1 + c α ) n coefficients in the Adair equation. Two equations can be derived, that express the fractional occupancy of the ligand binding site (Y) and the fraction of the proteins in the R state (R): Because of that, although the ligand may bind to the subunit when it is in either state, the binding of a ligand will increase the equilibrium in favor of the R state. The R state has a higher affinity for the ligand than the T state. ![]() Proteins with subunits in different states are not allowed by this model. That is to say, all subunits must be in either the R or the T state. In any one molecule, all protomers must be in the same state. In the historical model, each allosteric unit, called a protomer (generally assumed to be a subunit), can exist in two different conformational states – designated 'R' (for relaxed) or 'T' (for tense) states. In the models said of "induced-fit", those functions are identical. One crucial feature of the model is the dissociation between the binding function (the fraction of protein bound to the regulator), and the state function (the fraction of protein under the activated state), cf below. Phenomenologically, it looks as if the agonist provokes the conformational transition. For instance, an agonist will stabilize the active form of a pharmacological receptor. The regulators merely shift the equilibrium toward one state or another. Only the conformational change alters the affinity of a protomer for the ligand. The ligand can bind to a protomer in either conformation.Each protomer can exist in (at least) two conformational states, designated T and R these states are in equilibrium whether or not ligand is bound to the oligomer.An allosteric protein is an oligomer of protomers that are symmetrically related (for hemoglobin, we shall assume, for the sake of algebraic simplicity, that all four subunits are functionally identical).The ratio of the different conformational states is determined by thermal equilibrium. The main idea is that regulated proteins, such as many enzymes and receptors, exist in different interconvertible states in the absence of any regulator. The concept of two distinct symmetric states is the central postulate of the MWC model. It was proposed by Jean-Pierre Changeux in his PhD thesis, and described by Jacques Monod, Jeffries Wyman, and Jean-Pierre Changeux. ![]() In biochemistry, the Monod–Wyman–Changeux model ( MWC model, also known as the symmetry model) describes allosteric transitions of proteins made up of identical subunits. KNF model MWC model allostery heterotropic regulation.An allosteric transition of a protein between R and T states, stabilised by an Agonist, an Inhibitor and a Substrate. On the other hand, the relative contribution of tertiary and quaternary structural changes, as well as the asymmetry in the liganded state, may help distinguish between the two mechanisms. ![]() We find that isologous, mostly helical interfaces are common in cooperative proteins regardless of their mechanism. In this paper, we examine several cooperative proteins whose functional behavior, whether sequential or concerted, is established, and offer a combined approach based on functional and structural analysis. However, it is difficult to decide which model is more appropriate from equilibrium or kinetics measurements alone. Since its inception, this model of cooperativity was seen as distinct from and not reducible to the "sequential model" originally formulated by Pauling in 1935, which was developed further by Koshland, Nemethy, and Filmer in 1966. The definition was introduced by Monod and Jacob in 1963, and formally developed as the "concerted model" by Monod, Wyman, and Changeux in 1965. Allostery is a property of biological macromolecules featuring cooperative ligand binding and regulation of ligand affinity by effectors. ![]() Voigt is a vocally sumptuous although interpretively bland Helena, and Carl Tanner, if underpowered, brings more tonal allure to Menelaus’s impossible music than most tenors. For those who share the conductor’s enthusiasm, Telarc’s recording should make rewarding listening after the live-performance errors are patched up. There are gorgeous pages in this peculiar gloss on the postwar fate of Helen and Menelaus, but there are also long passages where the composer is clearly baffled by his librettist’s more esoteric flights of fancy, both in the original 1928 version (which Botstein prefers) and in the 1933 revision. This Strauss fan has been brooding over Die Ägyptische Helena for years but is still unconvinced, even by Botstein’s passionate advocacy (in my revisionist opinion, Strauss and Hofmannsthal reached their peak in Act One of Arabella). Then, too, Telarc was eager to record the opera with Voigt, now perhaps the leading Strauss soprano of the day, and here was one practical way to go about it. One is that Botstein is genuinely convinced that Die Ägyptische Helena is the misunderstood masterpiece of the Strauss-Hofmannsthal collaboration, and he plans to perform it until the rest of the world comes around. ![]() There are two possible explanations for this unexpected encore. Nothing if not persistent, Botstein and the ASO were back in Avery Fisher Hall recently, performing the same work, with Deborah Voigt once again singing the title role. ![]() It was nearly five years ago that leon Botstein led the American Symphony Orchestra in a concert performance of Richard Strauss’s Die Ägyptische Helena, the fifth and, according to conventional wisdom, the least of the composer’s six operatic collaborations with Hugo von Hofmannsthal. The Chicago Symphony has scarcely suffered under Barenboim’s leadership, and the sheer instrumental excellence of the playing was more than enough to start off Carnegie Hall’s new season on a high. I suppose anyone with many years of concertgoing might recall more stylish readings of these works (surely Ravel performances reached some kind of peak during Charles Munch’s reign over the Boston Symphony in the fifties), but I’m not inclined to complain. ![]() The CSO was also more or less on its own while Barenboim tended to the relatively modest yet omnipresent piano part of Falla’s Nights in the Gardens of Spain. Luckily, Barenboim allowed the music to speak for itself – he even stood mostly motionless, hands at his side, during the Boléro and let his virtuoso band develop this orchestrational tour de force. Such grandiose sophistry is hardly necessary, but this conductor has always had a way of making simple things seem complicated. Still, it seemed a bit much for conductor Daniel Barenboim to suggest that the four Ravel scores – Rapsodie Espagnole, Pavane Pour une Infante Défunte, Alborada del Gracioso, and Boléro – were consciously ordered to correspond to the traditional movements of a symphony. Nothing wrong with that – New York’s musical institutions have launched their new seasons with far less substantial fare, and the works heard on this occasion are popular for very good reasons. That gives you an idea of the easy-listening musical tone of the evening, an affair dominated by the Spanish-flavored works of Manuel de Falla and Maurice Ravel. Photo: Hiroyuki Itoįor its final encore at carnegie Hall’s opening concert of the season, the Chicago Symphony Orchestra sailed into “Tico-Tico,” a Brazilian specialty number made famous 60 years ago by that small icon of forties film camp, pop organist Ethel Smith. EASY LISTENING: Barenboim leads the CSO in a safe program at Carnegie. ![]() Legacy Platforms: PS4 - PS4 Pro - PS Vita - PS3 - PS2 - PS1 - PSP Spoilers must be tagged malicious spoilers will result in a ban. This subreddit is considered globally spoiler-free unless otherwise indicated. ![]() If linking to a social media post, please link directly to the original post. Secondary reporting is acceptable if the original source requires elaboration for the layman (patent filings, investor reports, etc). Please link to primary sources whenever possible. Please do not link to click-bait articles. Please ensure your post title is clear, descriptive, and accurately represents the content of the post. Please search the subreddit before submitting a new post - frequently-posted topics may be removed. When submitting breaking news, please check /r/PS5/new to make sure it has not already been posted. Please do not post news, articles, and other content that have been posted previously. 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The Future of Gaming - Post Discussion & RoundupĬlick here for detailed rules & policies.The Future of Gaming - Discussion & Video Collection.You can also check out another article on the game by following Digistatement. This was an article regarding the steps on how you can play Call of Duty Modern Warfare 2 together with a friend on a single monitor or TV. Finally, you now know how to play split-screen multiplayer online in the game.So, you can now play online multiplayer modes in split-screen with 2 players on the same display. After adding the second controller, you will notice that the game has detected it.Likewise, you have to select and sign in with a second account. After connecting your second controller, you have to press X/A to sign in. Now, you have to go back into the Multiplayer menu of the game and connect a second controller to your console. ![]() However, it is also important to note that you cannot play Ground War in split-screen mode. This is necessary because online split-screen multiplayer is not possible when Free-for-all mode is selected. Likewise, all of the game modes are selectable by default so all you have to do is deselect that mode.
You need to estimate the amount of income you expect to earn for the year. If you estimated your earnings too high, simply complete another Form 1040-ES worksheet to refigure your estimated tax for the next quarter. You can use the worksheet in Form 1040-ES to figure your estimated tax. Use your prior year's federal tax return as a guide. When figuring your estimated tax for the current year, it may be helpful to use your income, deductions, and credits for the prior year as a starting point. To figure your estimated tax, you must figure your expected adjusted gross income, taxable income, taxes, deductions, and credits for the year. Individuals, including sole proprietors, partners, and S corporation shareholders, generally use Form 1040-ES, to figure estimated tax. Nonresident aliens use Form 1040-ES(NR) to figure estimated tax. For additional information on how to figure your estimated tax, refer to Publication 505, Tax Withholding and Estimated Tax. ![]() You had no tax liability for the prior year if your total tax was zero or you didn’t have to file an income tax return.
![]() ![]() This is an idea I've been thinking about for a while now. The new ice stage (still working out some ground sprites) Settings page now works with Fullscreen toggle and Sound on/off buttons.Coins now move towards player within a certain range to keep up player momentum.(see gif below).New ice creatures which are faster (Flying and ground type).All Images, sprites etc shift to Blue palette.New "Ice Caverns" Stage Added ("Blue Theme")(see gif below).Below is a list of some of the new features I've added! I've been cleaning up my code structure and rewriting some of the more complicated scripts I wrote that were confusing myself. There's been plenty of 'under the hood' work done these past few weeks. It was one of the first that came to mind when working on this project and after lists and lists of possible names this one continued to stick out. The big news this week is we now have a name for the game- DELVEDOWN. Hey everyone! As you can see from above I am now up to version 0.3.8. UI and camera changes colour upon entering Depths 4, 5 and 6.Sound settings and more have yet to be implemented. Added Settings page with Fullscreen toggle.Game now logs and saves statistics (Deaths, coins collected, artifacts, wins etc).May apply this to coins too but at a shorter range. Diamonds that come from broken boxes attract quickly towards player.Spikes that are constantly falling from top will increase in speed as you venture further down.The higher the amount of keys required the better the reward. Some chests require keys (see gifs below).Equippable items no longer appear in the dungeons but can drop from Chests.Ground enemies can spawn on surfaces and patrol back and forth but will not follow player.Flying enemies now target the player and move towards them within a certain range.This means a player can drop off a surface and then jump mid air. Below is a full list of things added and things changed. It's been a while! A lot has being going on outside of my game development the last 2 weeks but I've been back at it the last few days and moving down the seemingly never ending list of things I want to add to this game. (Still need to work the kinks out on this one, so it may change in future. So there's a strange creature that will reset your items for you for a price. Sometimes, item combinations won't quite work out for you.Chests that can be opened for random loot or can be trapped.Artifacts a new rare spawning item that has it's own counter (indicated by Skulls).A Shrine where you can offer Artifacts for score.A Health shrine (which can be seen further below) which will heal you back to full Health for a price.Brief respite between every 3 levels and serves as the transition to the next area in which the difficulty heightens.I've added items, keys etc and now I have a place where they can be used, picked up, offered etc. Anyway, v0.3 is all about the In game store, stat recording and other small tweaks. Today I started working on v0.3 of my yet unnamed game! Which reminds I should probably pick a name soon. ![]() For instance, we were able to hit ranges of 55 feet, 60 feet, and all the way up to 65 feet reasonably easily. But what about actual performance? We found the Zombie Strike Doublestrike to be the epitome of a mixed bag in most measurable parameters. Here’s a quick GIF to illustrate the problem: The only remedy was to keep one hand in front of the blaster to hold the dart(s) in place, while the other hand is used to prime. Perhaps there is a tolerance issue or other quality control problem, but this happened to us over and over. It then becomes impossible to fire correctly. In practice, however, there’s one big problem: the Doublestrike’s cocking action allows the hammer to be pulled just a bit too far down, and when it comes back up into the cocked position, a small bit of air pushes the dart forward, unseating it from the chamber. Simply pull back on the hammer with a thumb, pull the trigger, and blast away! Or, so one would think. Thanks to the use of a “Smart AR (air restrictor)” system like that seem in the Elite Triad and Elite Rough Cut 2×4, one can fire a single dart from either of the two, muzzle-loaded barrels. Using the Zombie Strike Doublestrike should be fairly simple. It’s a bit of a chore, actually, which isn’t something you want in a hammer-primed blaster. ![]() It’s somewhat awkward to reach in this application, and isn’t particularly easy to cock. Unlike the Hammershot, the Doublestrike does not invite you to pull the hammer repeatedly. But a bigger issue is the hammer pull, which is small, and very uncomfortable to use. If your an adult with average-sized hands, your pinky finger will be left sitting uncomfortably on or below the bottom of the handle. It’s another thoughtful, balanced-looking design, which is what we’ve come to expect from the Nerf brand.Įrgonomically, the Doublestrike lives up to its “pocket pistol” billing, with a decidedly small handle that really only allows for a two-fingered grip (plus one on the trigger). We also love the faux handle wrap, and the “cut out” side chamber with Nerf detailing embossed. Out of the box, the Doublestrike doesn’t disappoint in the aesthetic department, with the aforementioned Derringer style double-barrel muzzle, bright colors, and cool Zombie Strike branding (hooray for actual paint instead of stupid stickers!). ![]() Of course, opening the actual box and removing the blaster seems to be getting harder and harder all the time (BOOMco is the worst), but overall, the shelf-appeal and packaging of the Doublestrike is spot-on. It’s very eye-pleasing, and just goes to show how far behind most competitors are in virtually every aspect of bringing quality blasters to market, all the way down to nailing the shelf presence. And the box design is pure Zombie Strike goodness, with a deft balance of Zombie grit mixed with bright, fun colors. The retail package is mostly open, allowing potential buyers to try out the hammer action right in the store (sans actual dart firing, of course). But we found the Doublestrike to be one nagging flaw shy of being the perfect pocket pistol for which we yearn.Įven before it’s taken out of the box, the Nerf Zombie Strike Doublestrike makes a good first impression. It’s a great concept, and a nice alternative to the bulky blasters many companies are producing. And that’s just what we’re getting with the Nerf Zombie Strike Doublestrike, which bears no small amount of resemblance to the classic Remington Model 95 Double Derringer. To learn more about how and for what purposes Amazon uses personal information (such as Amazon Store order history), please visit our Privacy Notice.With the success of the Nerf Zombie Strike Hammershot, it’s no huge surprise that Hasbro might look to create another one-handed, hammer-action blaster. You can change your choices at any time by visiting Cookie Preferences, as described in the Cookie Notice. Click ‘Customise Cookies’ to decline these cookies, make more detailed choices, or learn more. Third parties use cookies for their purposes of displaying and measuring personalised ads, generating audience insights, and developing and improving products. This includes using first- and third-party cookies, which store or access standard device information such as a unique identifier. If you agree, we’ll also use cookies to complement your shopping experience across the Amazon stores as described in our Cookie Notice. ![]() We also use these cookies to understand how customers use our services (for example, by measuring site visits) so we can make improvements. We use cookies and similar tools that are necessary to enable you to make purchases, to enhance your shopping experiences and to provide our services, as detailed in our Cookie Notice. ![]() ![]() Download a version of Office 2010 that is not an Office Click-to-Run product.After the Q: drive is made available, the installation does not display the error. Determine which application or which hardware uses the Q: drive letter, and then move it off the Q: drive by referring to the documentation from the manufacturer or to a support channel of the manufacturer for help.In order to successfully use the Office Click-to-Run version of Office Home and Business 2010 or of Office Home and Student 2010, use one of the following methods: How to resolve this error in Office Home and Student 2010 or in Office Home and Business 2010 To resolve this error, determine which application or which hardware uses the Q: drive letter, and then move it off the Q:drive by referring to the documentation from the manufacturer or to a support channel of the manufacturer for help. If the Q: drive letter is not available, the installation does not install Office Starter2010. How to resolve this error in Office Starter 2010 However, the installation of Office Click-to-Run requires this drive letter for Office 2010. This error means that the Q: drive letter is already being used by something else on your computer. When you try to install a product of Office 2010 by using Office Click-to-Run, the user encounters the following error: Note The Office Click-to-Run technology is also used in Microsoft Office Starter 2010. To download Office Click-to-Run for Microsoft Office Home and Student 2010 and for Microsoft Office Home and Business 2010, download the installation files from Microsoft directly. This separation lets Office 2010 coexist together with any existing version of Office that is already installed on your computer. This virtual space separates Office 2010 from the regular file system and from the other applications on your computer. Office Click-to-Run products also use Microsoft virtualization technology that stores Office 2010 in virtualized application space. Therefore, the rest of Office 2010 is being downloaded in the background quietly while you use one part of Office 2010. Similarly, you can start using Office 2010 before the whole suite or product is downloaded when you use Office Click-to-Run. When you watch a video on the web, you can watch the first part of the video before the whole file is downloaded. Office Click-to-Run products use streaming technology that is similar to watching a video on the web. Office Click-to-Run uses the virtualization and streaming technologies of Microsoft. Office Click-to-Run is a new way for broadband customers to obtain Microsoft Office and to update Office 2010. This technology is called Microsoft Office Click-to-Run, and this article discusses how Office Click-to-Run works and lists some frequently asked questions (FAQ). Microsoft is offering a new way to download and install products of Microsoft Office 2010. While most individuals naturally veer away from big boys like dinosaurs, there has been increasing interest in cloning things like dodo birds, woolly mammoths, and even the Tasmanian tiger. Among the strangest fantasies in recent years has been the resurrection of various species long extinct. Humans have long entertained some wild ideas, and the best individuals (like Michael Crichton) have written about them, raking in millions. Here’s everything you need to know about the science of resurrecting extinct animals and why some scientists say it’s time to stop playing God. The dodo lived solely in Mauritius and we know it was extinct by around 1680, less than 100 years after humans inhabited its island home. The land-dwelling, air-breathing dragons survived on the ark of Noah, and they have been dying out ever since (Genesis 6:20, 7:2122). Despite all the examples of what too much dabbling can do, however, a science company named Colossal Biosciences has ambitious plans to resurrect the long-extinct dodo bird and maybe even the woolly mammoth. The dodo ( Raphus cucullatus) is an extinct species of bird that once lived on Mauritius, an island off the coast of Madagascar. Scientists are piecing together clues about the life of the dodo, hundreds of years after the flightless bird was driven to extinction. Dragons, including the specific subset of dinosaurs, were real creatures and have simply died out due to sin, just like so many other animals, including the dodo. ![]() Of course, life didn’t find a way without a colossal boost from science, making the film a cautionary tale about science unbound (like Prometheus and Frankenstein’s monster). And who can forget about Ian Malcom‘s foreshadowing line, “Life finds a way”? ![]() Equally compelling were concepts like science run amuck and profound questions about ethics. It was a bird that went extinct over 300 years ago but is still one of the first things most people think about when they think about extinctions that were caused by human beings. Thirty years ago, Jurassic Park hit theaters in a big way, leaving audience members gobsmacked by some of the most lifelike dinosaur images ever to hit the silver screen. The Dodo Bird also known as Raphus cucullatus is an extinct and flightless bird that was endemic to the island of Mauritius. But while different kinds of dinosaurs are usually selected for prehistoric settings, there are a variety of other species of extinct animals that come to mind. MARP-ARMA abstracts will not be published but made available to all RehabWeek attendees in electronic form. MARP-ARMA only accepts submissions for POSTERS, not PLENARY PRESENTATIONS. PLEASE adhere closely to the instructions of each field! You will submit it as plain text into the text fields, we will take care of the formatting. Abstracts have to be submitted through this form. In the clinical abstract category, we expect submissions from practicing clinicians, that are neutral and provide both advantages and disadvantages of a device if they describe a clinical experience.Īll abstracts can be up to 2000 characters long including spaces. Companies wishing to promote their devices should get in contact with Kenes M+ to talk about sponsoring or exhibition opportunities. Please note that posters commercially promoting a specific device will not be accepted. Please note that the topic of these posters should still be about rehabilitation technology! No general clinical topics will be accepted. Examples could be a report about how a device, or several devices, were successfully integrated into a clinic, about an educational program that the clinic is conducting, about sharing a treatment plan, about how they managed to receive reimbursement for technology supported training or similar stories. These posters are NOT about research or scientific studies (but also not commercial promotion), but nevertheless information that is of interest to the people in this field. These posters are submitted by clinicians who have something to share that could benefit other attendees. Examples of such technologies can be found here: reports on studies in which people with physical disabilities train with technology to regain function, activities or the ability to participate in society. These are your typical conference abstracts about ongoing or completed research that has to do with the CLINICAL APPLICATION OF REHABILITATION TECHNOLOGY, i.e. MARP-ARMA will be accepting two different types of abstracts: Clinical posters are currently not eligible for the poster award. They will be eligible for the RehabWeek poster awards. The top scientific MARP-ARMA submissions will be selected for the poster fast forward sessions and asked to present their poster in 60 seconds during the conference. Poster presenters are expected to be registered for the conference, otherwise, their poster will be removed from the program. There will be a dedicated poster viewing and judging session in the main program, and poster presenters will also be expected to be present at their posters during certain coffee and lunch breaks (depending on the society to which you submit). The poster session will take place in the same place as the exhibition and the catering. Please do not submit the same work to different conferences, be respectful of the reviewer's time, thank you! Please note that while you are welcome to submit different projects to different RehabWeek conferences, the same work may only be submitted to one of the conferences. The abstract/paper submission is handled by each RehabWeek society/conference individually. PLEASE READ THESE INSTRUCTIONS CAREFULLY! There will be NO EXTENSIONS to this deadline! Please click the below button to submit your abstract. We are very much looking forward to RehabWeek and MARP-ARMA 2023 from September 24th to 28th in Singapore! We cordially invite you to participate by submitting your work and by taking the opportunity to discuss it and learn from RehabWeek attendees from different professional backgrounds. MARP-ARMA - Malaysian Association of Rehabilitation Physicians & ASEAN Rehabilitation Medicine Association.SRMS - The Society of Rehabilitation Medicine (Singapore).ISVR - International Society for Virtual Rehabilitation.IFESS - International Functional Electrical Stimulation Society.IISART - The International Industry Society in Advanced Rehabilitation Technology.ICORR - International Consortium for Rehabilitation Robotics (co-sponsored by IEEE RAS and IEEE EMBS). ![]() ![]() ACRM - The American Congress of Rehabilitation Medicine. |